Bhide S V, Maru G B, Sawai M M, Ranadive K J
Int J Cancer. 1978 Mar 15;21(3):381-6. doi: 10.1002/ijc.2910210320.
Tumorigenicity of isoniazid in Swiss and A strain mice was studied with three different doses (0.55, 1.1 and 2.2 mg/mouse/day). Mice were fed isoniazid by gastric intubation and killed when they appeared weak. Incidence of tumour ranged from 32 to 100%. Subsequently sex-specificity in isoniazid tumorigenicity was also studied as well as the effect of vitamin B complex or protein deficiency, and of transplacental exposure of Swiss strain embryos to isoniazid. It was observed that protein deficiency and transplacental exposure stimulated tumour incidence in mice treated with 0.55 mg of isoniazid. No sex specificity was observed in isoniazid tumorigenesis.
研究了异烟肼在瑞士小鼠和A系小鼠中的致瘤性，使用了三种不同剂量（0.55、1.1和2.2毫克/小鼠/天）。通过胃插管给小鼠喂食异烟肼，当它们显得虚弱时将其处死。肿瘤发生率在32%至100%之间。随后还研究了异烟肼致瘤性的性别特异性，以及复合维生素B或蛋白质缺乏的影响，以及瑞士品系胚胎经胎盘接触异烟肼的影响。观察到蛋白质缺乏和经胎盘接触会刺激接受0.55毫克异烟肼治疗的小鼠的肿瘤发生率。在异烟肼致瘤过程中未观察到性别特异性。
