Lee B Y, Trainor F S
Angiology. 1978 Apr;29(4):310-9. doi: 10.1177/000331977802900407.
In patients with severe peripheral vascular disease (mean arterial flow of 40 ml/min), a suspension of papaverine in a soft gelatin capsule produced plasma levels almost three times higher than those following treatment with a sustained-release tablet formulation. The higher plasma levels resulted in significantly greater vasodilation with increased distal arterial flow. The onset of peak pulsatile flow with the soft gelatin form came sooner than with the sustained-release form. However the durations of vasodilation were similar with both papaverine preparations. The vasodilatory activity of papaverine appeared to be greater in the sympathectomized leg. The soft gelatin formulation of papter reconstruction of a large artery, and may be effective in sustaining a longer vasodilatory effect in patients with small vessel disease, when surgical procedures may not be applicable.
在患有严重外周血管疾病（平均动脉血流量为40毫升/分钟）的患者中，软明胶胶囊中的罂粟碱混悬液产生的血浆水平几乎是使用缓释片剂制剂治疗后血浆水平的三倍。较高的血浆水平导致显著更大的血管舒张，远端动脉血流量增加。软明胶制剂出现峰值搏动血流的时间比缓释制剂更早。然而，两种罂粟碱制剂的血管舒张持续时间相似。罂粟碱的血管舒张活性在交感神经切除的腿部似乎更强。罂粟碱的软明胶制剂可能对大动脉重建有效，并且在手术方法可能不适用时，可能对维持小血管疾病患者更长时间的血管舒张作用有效。
