Thompson S H
Oral Surg Oral Med Oral Pathol. 1984 Jan;57(1):74-6. doi: 10.1016/0030-4220(84)90265-2.
Myoglobin is a protein with a molecular weight of 16,900 daltons that is normally found in adult and fetal striated and cardiac muscle cells. Its synthesis relates to the total ATP requirements of the muscle cell. The histogenesis of the granular cell tumor is controversial, but an origin from striated muscle has been postulated. Seven cases of tongue GCT were evaluated for the presence of myoglobin using the unlabeled antibody (PAP) technique. Normal human striated muscle was used for both positive and negative controls. None of the tumors showed positive staining of the granular cells. Positive controls showed specificity of staining for skeletal muscle. The negative controls did not stain. Granular cell tumors of the tongue do not appear to contain myoglobin. This suggests that either the GCT is not of muscle origin or that, if it is, there may be a metabolic change in the granular cells so that myoglobin is not synthesized. It may be possible that a change in the antigenic determinant has occurred.
肌红蛋白是一种分子量为16,900道尔顿的蛋白质，正常存在于成人和胎儿的横纹肌及心肌细胞中。其合成与肌肉细胞的总ATP需求相关。颗粒细胞瘤的组织发生存在争议，但推测其起源于横纹肌。使用未标记抗体（PAP）技术对7例舌部颗粒细胞瘤进行肌红蛋白检测评估。正常人类横纹肌用作阳性和阴性对照。所有肿瘤的颗粒细胞均未显示阳性染色。阳性对照显示出骨骼肌染色的特异性。阴性对照未染色。舌部颗粒细胞瘤似乎不含肌红蛋白。这表明要么颗粒细胞瘤不是肌肉起源，要么如果是肌肉起源，颗粒细胞可能发生了代谢变化，以至于不合成肌红蛋白。也有可能抗原决定簇发生了变化。
