Miki T, Shirabe K, Ebina Y, Nakazawa A
Nucleic Acids Res. 1984 Jan 25;12(2):1203-17.
The lexA gene of Escherichia coli encodes a repressor of the genes whose expression is induced by the agents that result in DNA damage. In vivo transcripts of the lexA gene consisted of two species; mRNA-1 of 673 bases and mRNA-2 of approximately 3,000 bases. The transcription in vivo started at a site which was two-base pairs downstream from the in vitro initiation site reported previously. The majority of the transcription stopped at a series of T residues preceeded by a dyad symmetry located immediately after the lexA gene. A small fraction of the transcription passed through the termination site to form the mRNA of downstream gene(s) which would be related to the "SOS functions".
大肠杆菌的lexA基因编码一种阻遏蛋白，该阻遏蛋白作用于那些其表达受导致DNA损伤的因子诱导的基因。lexA基因的体内转录本有两种；一种是673个碱基的mRNA-1，另一种是约3000个碱基的mRNA-2。体内转录起始于一个位点，该位点位于先前报道的体外起始位点下游两个碱基对处。大部分转录在一系列T残基处终止，这些T残基之前是位于lexA基因之后紧邻的一个二重对称结构。一小部分转录会通过终止位点，形成与“ SOS功能”相关的下游基因的mRNA。
