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不同的牛白血病病毒诱导的肿瘤在不同染色体中含有前病毒。

Different bovine leukemia virus-induced tumors harbor the provirus in different chromosomes.

作者信息

Grégoire D, Couez D, Deschamps J, Heuertz S, Hors-Cayla M C, Szpirer J, Szpirer C, Burny A, Huez G, Kettmann R

出版信息

J Virol. 1984 Apr;50(1):275-9. doi: 10.1128/JVI.50.1.275-279.1984.

DOI:10.1128/JVI.50.1.275-279.1984
PMID:6321797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC255611/
Abstract

DNAs from 25 independent hamster X bovine somatic cell hybrids were submitted to the Southern blot analysis with probes made of unique cellular fragments adjacent to single-copy proviruses from three different bovine tumors. It appeared that these cellular sequences, and thus the respective proviruses, belonged to three different chromosomes in the three different tumors examined.

摘要

从25个独立的仓鼠X牛体细胞杂种中提取的DNA，用来自三种不同牛肿瘤的单拷贝前病毒附近的独特细胞片段制成的探针进行Southern印迹分析。结果表明，这些细胞序列以及相应的前病毒，在所检测的三种不同肿瘤中属于三条不同的染色体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f95/255611/82fe67518022/jvirol00133-0285-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f95/255611/9a3adc122a29/jvirol00133-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f95/255611/82fe67518022/jvirol00133-0285-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f95/255611/9a3adc122a29/jvirol00133-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f95/255611/82fe67518022/jvirol00133-0285-a.jpg

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本文引用的文献

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Cattle gene mapping by somatic cell hybridization study of 17 enzyme markers.通过对17种酶标记物进行体细胞杂交研究绘制牛基因图谱。
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Chromosome integration domain for bovine leukemia provirus in tumors.肿瘤中牛白血病原病毒的染色体整合结构域
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