Kawakami Y, Matsuwaka S, Otani T, Kondo H, Nakamura S
J Antibiot (Tokyo). 1978 Feb;31(2):112-6. doi: 10.7164/antibiotics.31.112.
A new antifungal antibiotic, named ileumycin, was isolated from culture broth of streptomyces H 698-SY2, which was identified as S. lavendulae. The antibiotic was recovered from the culture filtrate by adsorption on Amberlite XAD-II and elution with aqueous methanol and was further purified by ion-exchange column chromatography on SE-cellulose and followed by partition chromatography on silica gel. The antibiotic was named ileumycin, because isoleucine was detected in the acid hydrolyzate of the antibiotic. Ileumycin exhibited antimicrobial activity against only a few species of fungi.
一种名为回肠霉素的新型抗真菌抗生素，是从链霉菌H 698 - SY2的培养液中分离出来的，该链霉菌被鉴定为薰衣草链霉菌。通过在Amberlite XAD - II上吸附并用水性甲醇洗脱，从培养滤液中回收该抗生素，然后通过在SE - 纤维素上进行离子交换柱色谱法，接着在硅胶上进行分配色谱法进一步纯化。该抗生素被命名为回肠霉素，因为在该抗生素的酸水解产物中检测到了异亮氨酸。回肠霉素仅对少数几种真菌表现出抗菌活性。
