Lai F M, Herzlinger H, Cervoni P
Res Commun Chem Pathol Pharmacol. 1984 Jan;43(1):55-65.
Aorta-coarcted hypertensive rats (AHR) and sham-operated normotensive rats (SNR) were compared in order to assess the effect of elevated blood pressure (BP) on the concentration and affinity of cardiac adrenoceptors in these rats at different stages of hypertension. Body weight was significantly reduced, mean arterial blood pressure (MABP) and the ratio by ventricle/body weight (index of hypertropy) were significantly increased in coarcted rats at 2, 6 and 28 days after ligation of the abdominal aorta. Myocardial membranes prepared from hypertensive rats at various stages of hypertension contained the same concentration of cardiac alpha-adrenoceptors as compared to corresponding time-matched, sham-operated controls. In addition, the receptor affinity for the radioligand was similar between hypertensive rats and their respective controls. Thus, aorta-coarctation induced hypertension is not associated with any alterations in cardiac alpha-adrenoceptors, which is different from reports in other models of experimental hypertension.
为了评估血压升高对主动脉缩窄性高血压大鼠（AHR）和假手术正常血压大鼠（SNR）在高血压不同阶段心脏肾上腺素能受体浓度和亲和力的影响，对这两种大鼠进行了比较。在结扎腹主动脉后2天、6天和28天，缩窄大鼠的体重显著降低，平均动脉血压（MABP）和心室/体重比（肥大指数）显著升高。与相应时间匹配的假手术对照组相比，处于高血压不同阶段的高血压大鼠制备的心肌膜中，心脏α-肾上腺素能受体浓度相同。此外，高血压大鼠与其各自对照组之间，放射性配体与受体的亲和力相似。因此，主动脉缩窄诱导的高血压与心脏α-肾上腺素能受体的任何改变均无关，这与其他实验性高血压模型的报道不同。
