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[大疱性类天疱疮。当前研究进展]

[Bullous pemphigoid. Current aspects].

作者信息

Bernard P, Rommel A

出版信息

Sem Hop. 1984 Jan 19;60(2):125-30.

PMID:6322327
Abstract

Bullous pemphigoid is characterized, since the use of cutaneous immunofluorescence as a routine technique, by a linear deposition of IgG and C3 in the basal membrane zone. This has led to the description of unusual clinical aspects and onset forms which were formerly unrecognized. Insight into the intricate mechanism of dermo-epidermal separation, which is the basic defect of the disease, has very lately been gained by immunologic and electronic microscopy studies. However, at present, the nosologic position of bullous pemphigoid in relation to herpes gestationnis and cicatricial pemphigoid cannot be satisfactorily specified. The exact outcome is still poorly known. This is probably due to a poorly standardized management. Systemic corticotherapy, although not the only treatment, still provides the best results.

摘要

自从将皮肤免疫荧光作为常规技术以来,大疱性类天疱疮的特征是IgG和C3在基底膜带呈线性沉积。这使得人们对以前未被认识的不寻常临床症状和发病形式有了描述。通过免疫和电子显微镜研究,最近对真皮-表皮分离这一疾病的基本缺陷的复杂机制有了深入了解。然而,目前大疱性类天疱疮在妊娠疱疹和瘢痕性类天疱疮方面的疾病分类位置仍不能令人满意地确定。确切的结果仍然知之甚少。这可能是由于管理缺乏标准化。全身皮质激素治疗虽然不是唯一的治疗方法,但仍然能提供最好的效果。

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Bullous pemphigoid.大疱性类天疱疮
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