Puolakka J, Tuimala R
Acta Obstet Gynecol Scand. 1983;62(6):575-7. doi: 10.3109/00016348309156251.
Oral ketoconazole and topical miconazole were compared in the treatment of vaginal candidiasis, in an open trial. One group (n = 49) received of ketoconazole, 400 mg per day for 3 days, another group (n = 42) ketoconazole 200 mg per day for 6 days and the third (n = 49) miconazole vaginal tablets (100 mg) one per day for 14 days. One week after conclusion of the treatment the mycological cure rates (67%, 78% and 81%) were not statistically different from each other. The recurrence rates assessed one month after the treatment were also of same order (7%, 7% and 15%) and did not differ significantly from each other. Those patients who had previous had candidiasis showed lower cure rates than patients with their first vaginal candidiasis., following both miconazole and ketoconazole therapy. No adverse reactions attributable to the drugs were recorded. The advantages of ketoconazole in the treatment of vaginal candidiasis are: oral route of administration, short duration of the therapy (3-6 days), high therapeutic effectiveness and lack of any significant side effects.
在一项开放性试验中，对口服酮康唑和局部使用咪康唑治疗阴道念珠菌病进行了比较。一组（n = 49）接受酮康唑治疗，每天400毫克，共3天；另一组（n = 42）接受酮康唑治疗，每天200毫克，共6天；第三组（n = 49）接受咪康唑阴道片（100毫克）治疗，每天一片，共14天。治疗结束一周后，真菌学治愈率（分别为67%、78%和81%）在统计学上无显著差异。治疗后一个月评估的复发率也处于同一水平（分别为7%、7%和15%），彼此之间无显著差异。在咪康唑和酮康唑治疗后，既往有念珠菌病的患者治愈率低于首次患阴道念珠菌病的患者。未记录到与药物相关的不良反应。酮康唑治疗阴道念珠菌病的优点包括：口服给药途径、治疗时间短（3 - 6天）、治疗效果高且无任何明显副作用。
