Sharma J B, Buckshee K, Gulati N
Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi.
Aust N Z J Obstet Gynaecol. 1991 Aug;31(3):276-8. doi: 10.1111/j.1479-828x.1991.tb02798.x.
This prospective study was carried out on 250 patients having clinical and mycological evidence of vaginal candidosis. One hundred patients received ketoconazole orally (400 mg/day for 5 days), another 100 patients received miconazole vaginal pessary treatment (one 100 mg tablet locally for 14 days), while the other 50 patients received combination therapy of oral ketoconazole and miconazole vaginal tablets. Although all 3 regimens were significantly effective in relieving patients symptoms and physical signs, the combination therapy gave the best results. There was 98% symptomatic relief with the combination therapy in contrast to 82% and 78% in the oral ketocanozole and vaginal micronazole groups respectively (p less than 0.001). Mycological cure rates were also significantly higher in the combination therapy group (94% versus 80% and 76%). The relapse rate was least in the combination group 2% versus 8% and 12%. The combination therapy is recommended for the best results in vaginal candidosis.
这项前瞻性研究针对250例有阴道念珠菌病临床和真菌学证据的患者开展。100例患者口服酮康唑（400毫克/天，共5天），另外100例患者接受咪康唑阴道栓剂治疗（局部使用1片100毫克片剂，共14天），而其余50例患者接受口服酮康唑和咪康唑阴道片的联合治疗。尽管所有3种治疗方案在缓解患者症状和体征方面均有显著效果，但联合治疗效果最佳。联合治疗的症状缓解率为98%，相比之下，口服酮康唑组和阴道用咪康唑组分别为82%和78%（P<0.001）。联合治疗组的真菌治愈率也显著更高（94%，相比之下分别为80%和76%）。联合治疗组的复发率最低（2%，相比之下分别为8%和12%）。对于阴道念珠菌病，为获得最佳疗效，推荐采用联合治疗。
