Riikonen R
Acta Paediatr Scand. 1984 Jan;73(1):1-12. doi: 10.1111/j.1651-2227.1984.tb09889.x.
Data on incidence, aetiology, therapy and prognosis of infantile spasms are reviewed. In a large proportion of cases the aetiological factors of infantile spasms can now be established with some certainty. Especially the new neuroradiological and virological investigative methods have enabled a more accurate diagnosis. There have been changes in the aetiologic pattern over the years. The optimal dosage and duration of ACTH or glucocorticoid therapy have not yet been established. In the Finnish study the large ACTH doses (120-160 IE) generally used in many Nordic countries did not carry a better prognosis than the smaller doses (20-40 IE). Side-effects of ACTH therapy are relatively common. They are more frequent with large doses than with smaller ones. Measures can be taken to prevent or treat part of them. The prognosis and related factors in infantile spasms as well as some recommendations to improve them are reviewed.
本文综述了婴儿痉挛症的发病率、病因、治疗及预后相关数据。目前，在很大一部分病例中，婴儿痉挛症的病因已能得到一定程度的确立。尤其是新的神经放射学和病毒学检查方法使得诊断更为准确。多年来，病因模式已发生变化。促肾上腺皮质激素（ACTH）或糖皮质激素治疗的最佳剂量和疗程尚未确定。在芬兰的研究中，许多北欧国家普遍使用的大剂量ACTH（120 - 160国际单位）相比小剂量（20 - 40国际单位），预后并未更好。ACTH治疗的副作用相对常见，大剂量时比小剂量时更频繁。可以采取措施预防或治疗其中部分副作用。本文还综述了婴儿痉挛症的预后及相关因素，以及一些改善预后的建议。
