巨细胞病毒性视网膜炎的α干扰素治疗
Alpha-interferon administration in cytomegalovirus retinitis.
作者信息
Chou S W, Dylewski J S, Gaynon M W, Egbert P R, Merigan T C
出版信息
Antimicrob Agents Chemother. 1984 Jan;25(1):25-8. doi: 10.1128/AAC.25.1.25.
Abstract
Four patients, including three with the acquired immunodeficiency syndrome (AIDS), were treated with high-dose, buffy coat-derived alpha-interferon for progressive cytomegalovirus retinitis. Two of these patients had decreased viruria during therapy and the other two had increased viruria. There was evidence of progression of disease despite therapy in all patients, although the retinitis eventually became quiescent in the patient without AIDS. The severe immunosuppression encountered in AIDS patients complicates the management of cytomegalovirus and other opportunistic infections.
摘要
四名患者，包括三名获得性免疫缺陷综合征（艾滋病）患者，接受了高剂量的、从 Buffy 层提取的α干扰素治疗进行性巨细胞病毒性视网膜炎。其中两名患者在治疗期间病毒尿减少，另外两名患者病毒尿增加。尽管对所有患者都进行了治疗，但仍有疾病进展的证据，不过在没有艾滋病的患者中视网膜炎最终静止。艾滋病患者中遇到的严重免疫抑制使巨细胞病毒和其他机会性感染的管理变得复杂。
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