辅助性巨细胞病毒静脉注射免疫球蛋白未能提高更昔洛韦对获得性免疫缺陷综合征合并巨细胞病毒性视网膜炎患者的疗效：一项1期研究。
Failure of adjunctive cytomegalovirus intravenous immune globulin to improve efficacy of ganciclovir in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: a phase 1 study.
作者信息
Jacobson M A, O'Donnell J J, Rousell R, Dionian B, Mills J
机构信息
Medical Service, San Francisco General Hospital, California 94110.
出版信息
Antimicrob Agents Chemother. 1990 Jan;34(1):176-8. doi: 10.1128/AAC.34.1.176.
Abstract
Six men with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus (CMV) retinitis, treated with combined ganciclovir induction therapy and hyperimmune globulin (CMV-IGIV) for 10 days followed by CMV-IGIV alone, had a median time to retinitis progression shorter (7 days) than had eight historical controls given ganciclovir maintenance therapy (54 days; P = 0.06) and similar to that in eight controls given ganciclovir for 10 days only (19 days; P = 0.97). CMV-IGIV, which also failed to inhibit CMV replication in blood and urine, did not appear to add markedly to the efficacy of ganciclovir in acquired immunodeficiency syndrome-associated CMV retinitis.
摘要
六名患有获得性免疫缺陷综合征（AIDS）和巨细胞病毒（CMV）视网膜炎的男性，接受了更昔洛韦诱导联合治疗和高免疫球蛋白（CMV-IGIV）治疗10天，随后仅接受CMV-IGIV治疗，其视网膜炎进展的中位时间（7天）比八名接受更昔洛韦维持治疗的历史对照患者（54天；P = 0.06）短，且与八名仅接受更昔洛韦治疗10天的对照患者（19天；P = 0.97）相似。CMV-IGIV在血液和尿液中也未能抑制CMV复制，在获得性免疫缺陷综合征相关的CMV视网膜炎中，它似乎并未显著增加更昔洛韦的疗效。
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