de Almeida M A, Kapczinski F P, Izquierdo I
Behav Neural Biol. 1983 Nov;39(2):277-83. doi: 10.1016/s0163-1047(83)90961-5.
Post-training introparitoneal (ip) administration of ACTH1-24 (25 ng/rat) or epinephrine HCl (625 ng/rat) facilitated retention of a step-down inhibitory avoidance task acquired using a small start platform (5-cm high, 25 X 7 cm) and a low intensity training footshock (0.3 mA, 60 Hz), and caused retrograde amnesia for a similar task acquired using a large platform (5-cm high, 25 X 25 cm) and a high intensity training footshock (0.8 mA, 60 Hz). The post-training intracerebroventricular (icv) administration of 5, 25, or 125 ng/rat of ACTH or of 5, 25, 125, 625, or 1250 ng/rat of epinephrine had no effect on retention of either task. These findings suggest that memory modulation by ACTH and epinephrine is mediated by reflexes initiated at peripheral receptors that affect brain activity during the post-training period.
训练后腹腔内注射促肾上腺皮质激素1-24（25纳克/大鼠）或盐酸肾上腺素（625纳克/大鼠），有助于保留使用小起始平台（5厘米高，25×7厘米）和低强度训练电击（0.3毫安，60赫兹）习得的一步下抑制性回避任务，并且会导致对使用大平台（5厘米高，25×25厘米）和高强度训练电击（0.8毫安，60赫兹）习得的类似任务产生逆行性遗忘。训练后脑室内注射5、25或125纳克/大鼠的促肾上腺皮质激素，或5、25、125、625或1250纳克/大鼠的肾上腺素，对这两种任务的保留均无影响。这些发现表明，促肾上腺皮质激素和肾上腺素对记忆的调节是由外周受体引发的反射介导的，这些反射在训练后期间影响大脑活动。
