Alpers C E, Beckstead J H, Newman A B
Cancer. 1984 May 1;53(9):1943-7. doi: 10.1002/1097-0142(19840501)53:9<1943::aid-cncr2820530923>3.0.co;2-0.
A 74-year-old man developed a locally invasive malignant fibrous histiocytoma of the scalp with multiple facial recurrences and concomitant hematopoietic dysplasia occurring over a 2-year period. One month prior to his death, his hematologic profile evolved into myelomonocytic leukemia. Mixed cellularity Hodgkin's disease involving mediastinal and periportal lymph nodes, which was not suspected antemortem, was discovered at autopsy. In the experience of the authors, this association of neoplasms is unique and raises the possibility in this case of an unidentified stimulus to neoplastic transformation of cells of histiocyte/monocyte origin.
一名74岁男性在两年内发生了头皮局部侵袭性恶性纤维组织细胞瘤，伴有多次面部复发以及并发造血发育异常。在其死亡前一个月，血液学检查结果演变为骨髓单核细胞白血病。尸检发现有累及纵隔和门静脉周围淋巴结的混合细胞型霍奇金病，生前未被怀疑。据作者经验，这种肿瘤的关联是独特的，并且在该病例中增加了存在未明刺激因素促使组织细胞/单核细胞起源细胞发生肿瘤转化的可能性。
