van der Valk P, Meijer C J, Willemze R, van Oosterom A T, Spaander P J, te Velde J
Histopathology. 1984 Jan;8(1):105-23. doi: 10.1111/j.1365-2559.1984.tb02326.x.
Large-cell non-Hodgkin's lymphomas (T- and B-immunoblastic, centroblastic and true histiocytic lymphomas) have a heterogeneous clinical course. In the present study the clinical and morphological data of 20 cases of histiocytic sarcoma (true histiocytic lymphoma) are presented. Diagnosis was supported by immunohistochemistry, cytochemistry, rosette assays and/or electron microscopy. Although the follow-up was relatively short (up to 144 months, mean 26 months), the clinical data differed clearly from the series of large-cell non-Hodgkin lymphomas, recorded in the literature. Differences were found in age distribution with a peak in the third decade, in organ involvement showing a preference for skin, gastrointestinal tract and bone, and in response to therapy. In general, histiocytic sarcoma appears to have a more favourable response to therapy and clinical course than the other large-cell lymphomas (T- and B-immunoblastic and centroblastic lymphomas). Moreover, preliminary observations in the group of histiocytic sarcomas suggested that the presence of lysozyme and/or 5-nucleotidase and the absence of alpha 1-antitrypsin in the cytoplasm is associated with a better response to therapy and favourable clinical course.
大细胞非霍奇金淋巴瘤（T和B免疫母细胞性、中心母细胞性和真性组织细胞性淋巴瘤）具有异质性的临床病程。在本研究中，呈现了20例组织细胞肉瘤（真性组织细胞性淋巴瘤）的临床和形态学数据。诊断通过免疫组织化学、细胞化学、玫瑰花结试验和/或电子显微镜检查得以支持。尽管随访时间相对较短（最长144个月，平均26个月），但临床数据与文献中记录的大细胞非霍奇金淋巴瘤系列明显不同。在年龄分布上发现差异，第三个十年出现峰值；在器官受累方面，表现为对皮肤、胃肠道和骨骼有偏好；在对治疗的反应方面也存在差异。总体而言，组织细胞肉瘤似乎比其他大细胞淋巴瘤（T和B免疫母细胞性淋巴瘤以及中心母细胞性淋巴瘤）对治疗的反应更好，临床病程也更佳。此外，对组织细胞肉瘤组的初步观察表明，细胞质中存在溶菌酶和/或5-核苷酸酶且不存在α1-抗胰蛋白酶与对治疗的更好反应及良好的临床病程相关。
