Camisa C, Kraut E, Jayanthi-Zvara B
J Invest Dermatol. 1984 Apr;82(4):318-21. doi: 10.1111/1523-1747.ep12260613.
Previous studies have demonstrated alterations in polymorphonuclear leukocyte (PMNL) function in patients with psoriasis, but results have been variable. In this study we attempted to determine whether functional changes in PMNL from psoriatics represented an intrinsic cellular defect or a response to factors in serum. We evaluated the effect of the continuous presence of autologous and heterologous serum on lysozyme release and superoxide anion (O2-) generation by psoriatic and normal PMNL exposed to a soluble or particulate phagocytic stimulus. There were no differences in O2- generation or lysozyme release between normal and psoriatic PMNL without serum. However, in the presence of 10% autologous serum, these responses were significantly decreased for psoriatic PMNL (p less than .001). The results were not time-dependent and did not correlate with the extent of psoriatic involvement. The data support the hypothesis that serum factors exist in patients with psoriasis that may affect PMNL functions. The presence or absence of such factors could explain, in part, the differences between the various investigations of PMNL function in psoriasis.
以往研究表明，银屑病患者的多形核白细胞（PMNL）功能存在改变，但结果不一。在本研究中，我们试图确定银屑病患者PMNL的功能变化是代表内在细胞缺陷还是对血清中因子的反应。我们评估了自体和异源血清持续存在对暴露于可溶性或颗粒性吞噬刺激物的银屑病患者和正常PMNL释放溶菌酶和产生超氧阴离子（O2-）的影响。无血清时，正常和银屑病患者的PMNL在O2-产生或溶菌酶释放方面没有差异。然而，在存在10%自体血清的情况下，银屑病患者的PMNL的这些反应显著降低（p小于0.001）。结果与时间无关，也与银屑病的累及程度无关。数据支持以下假设：银屑病患者体内存在可能影响PMNL功能的血清因子。这些因子的存在与否可以部分解释银屑病中PMNL功能各种研究之间的差异。
