伴有和不伴有乙肝表面抗原（HBsAg）的酗酒者以及非酒精性HBsAg阳性患者的肝硬化形态学和肝细胞癌的发生情况。一项对比尸检研究。

Morphology of cirrhosis and occurrence of hepatocellular carcinoma in alcoholics with and without HBsAg and in non-alcoholic HBsAg-positive patients. A comparative autopsy study.

作者信息

Nakanuma Y, Ohta G

出版信息

Liver. 1983 Aug;3(4):231-7. doi: 10.1111/j.1600-0676.1983.tb00873.x.

DOI:10.1111/j.1600-0676.1983.tb00873.x

Abstract

The morphology of liver cirrhosis and the incidence of hepatocellular carcinoma (HCC) in HBsAg-positive alcoholics (17 cases) were examined and compared with those of HBsAg-negative alcoholics (31 cases) and HBsAg-positive non-alcoholics (59 cases). These materials were obtained from our autopsy cases during the last 9 years. About 70% of the 17 showed macronodular cirrhosis, in which periportal and portal lymphoid cell infiltration and liver cell dysplasia were often present, as seen in HBsAg positive non-alcoholics. Furthermore, the liver weight and age distribution at autopsy in HBsAg-positive alcoholics were similar to those of HBsAg-positive non-alcoholics and different from those of HBsAg-negative alcoholics. The association rate of HCC was very high in HBsAg-positive alcoholics (64.7%), similar to that in HBsAg-positive non-alcoholics (67.8%), while the rate in HBsAg-negative alcoholics was low (22.6%). It therefore seems likely that in HBsAg-positive alcoholics concomitant HB virus infection has a major effect on the development of cirrhosis, especially a macronodular type, and on HCC formation.

摘要

对17例HBsAg阳性酗酒者、31例HBsAg阴性酗酒者以及59例HBsAg阳性非酗酒者的肝硬化形态及肝细胞癌（HCC）发病率进行了检查，并相互比较。这些材料取自过去9年我们的尸检病例。17例中的约70%表现为大结节性肝硬化，其中常可见汇管区和门静脉淋巴样细胞浸润以及肝细胞发育异常，这与HBsAg阳性非酗酒者所见相同。此外，HBsAg阳性酗酒者尸检时的肝脏重量和年龄分布与HBsAg阳性非酗酒者相似，而与HBsAg阴性酗酒者不同。HBsAg阳性酗酒者的HCC关联率非常高（64.7%），与HBsAg阳性非酗酒者（67.8%）相似，而HBsAg阴性酗酒者的HCC关联率较低（22.6%）。因此，HBsAg阳性酗酒者中，伴随的乙肝病毒感染似乎对肝硬化尤其是大结节型肝硬化的发展以及HCC的形成有主要影响。