Giovanni B, Giuseppina C M, Susanna F, Roberto M
Microvasc Res. 1984 Jan;27(1):110-3. doi: 10.1016/0026-2862(84)90045-1.
The effect of isoprenaline infusion (1 gamma/min) on blood flow in the extremities was studied in 15 Raynaud's disease (RD) patients and 9 healthy controls. A highly significant (P less than 0.0005) decrease in blood flow was seen in the RD subjects. It is suggested that an increased presynaptic beta receptor response to cold and emotional stimulus may be involved in the physiopathogenesis of RD.
对15名雷诺氏病（RD）患者和9名健康对照者研究了静脉输注异丙肾上腺素（1微克/分钟）对肢体血流的影响。在RD受试者中观察到血流显著减少（P<0.0005）。提示对寒冷和情绪刺激的突触前β受体反应增强可能参与了RD的病理生理过程。
