Freedman R R, Sabharal S C, Desai N, Wenig P, Mayes M
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan.
Arthritis Rheum. 1989 Jan;32(1):61-5. doi: 10.1002/anr.1780320110.
In our study of 28 patients with idiopathic Raynaud's disease, the patients had significantly greater digital blood flow responses to intraarterial phenylephrine and clonidine than did normal control subjects. There were no group differences in finger blood flow responses to body heating, reflex cooling, digital ischemia, or to intraarterial tyramine or isoproterenol. There were also no group differences in blood pressure or heart rate during any procedure. These results suggest that patients with idiopathic Raynaud's disease have increased peripheral vascular alpha-adrenergic receptor sensitivity and/or density compared with normal persons.
在我们对28例特发性雷诺病患者的研究中，这些患者对动脉内注射去氧肾上腺素和可乐定的指端血流反应明显大于正常对照受试者。在手指血流对身体加热、反射性冷却、指端缺血，或对动脉内注射酪胺或异丙肾上腺素的反应方面，两组之间没有差异。在任何操作过程中，两组的血压或心率也没有差异。这些结果表明，与正常人相比，特发性雷诺病患者外周血管α-肾上腺素能受体的敏感性和/或密度增加。
