吲哚美辛对巨噬细胞抑制MOPC - 315肿瘤细胞作用的刺激，受到前列腺素E2和脂氧合酶抑制剂去甲二氢愈创木酸的抑制。
Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is inhibited by both prostaglandin E2 and nordihydroguaiaretic acid, a lipoxygenase inhibitor.
作者信息
Elliott G R, Tak C, Pellens C, Ben-Efraim S, Bonta I L
机构信息
Department of Pharmacology, Medical Faculty, Erasmus University Rotterdam, The Netherlands.
出版信息
Cancer Immunol Immunother. 1988;27(2):133-6. doi: 10.1007/BF00200017.
Abstract
Indomethacin enhanced macrophage cytostasis against MOPC-315 tumor cells in vitro. The effect of indomethacin was inhibited by prostaglandin E2 and by the lipoxygenase inhibitor nordihydroguaiaretic acid. Prostaglandin E2 and nordihydroguaiaretic acid also inhibited indomethacin stimulation of macrophage thymidine incorporation. Indomethacin inhibited macrophage prostaglandin E2 formation and stimulated leukotriene B4 synthesis. Nordihydroguaiaretic acid inhibited leukotriene B4 production. Our data indicate that eicosanoids play a role in regulating macrophage cytostasis.
摘要
吲哚美辛在体外增强了巨噬细胞对MOPC - 315肿瘤细胞的细胞生长抑制作用。前列腺素E2和脂氧合酶抑制剂去甲二氢愈创木酸可抑制吲哚美辛的作用。前列腺素E2和去甲二氢愈创木酸也抑制吲哚美辛刺激的巨噬细胞胸腺嘧啶核苷掺入。吲哚美辛抑制巨噬细胞前列腺素E2的形成并刺激白三烯B4的合成。去甲二氢愈创木酸抑制白三烯B4的产生。我们的数据表明，类花生酸在调节巨噬细胞细胞生长抑制中起作用。
相似文献
1
Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is inhibited by both prostaglandin E2 and nordihydroguaiaretic acid, a lipoxygenase inhibitor.吲哚美辛对巨噬细胞抑制MOPC - 315肿瘤细胞作用的刺激，受到前列腺素E2和脂氧合酶抑制剂去甲二氢愈创木酸的抑制。
Cancer Immunol Immunother. 1988;27(2):133-6. doi: 10.1007/BF00200017.
2
Prostaglandin E2 inhibits and indomethacin and aspirin enhance, A23187-stimulated leukotriene B4 synthesis by rat peritoneal macrophages.前列腺素E2抑制，而消炎痛和阿司匹林增强A23187刺激的大鼠腹腔巨噬细胞白三烯B4的合成。
Br J Pharmacol. 1989 Feb;96(2):265-70. doi: 10.1111/j.1476-5381.1989.tb11812.x.
3
Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is enhanced by endogenous metabolites of lipoxygenase and counteracted by prostaglandin E2.消炎痛对巨噬细胞抑制MOPC - 315肿瘤细胞生长的刺激作用可被脂氧合酶的内源性代谢产物增强，并被前列腺素E2抵消。
Agents Actions. 1989 Jan;26(1-2):167-9. doi: 10.1007/BF02126596.
4
Regulation of macrophage-derived fibroblast growth factor release by arachidonate metabolites.花生四烯酸代谢产物对巨噬细胞衍生的成纤维细胞生长因子释放的调节
J Leukoc Biol. 1987 Aug;42(2):106-13. doi: 10.1002/jlb.42.2.106.
5
Leukotriene synthesis by human gastrointestinal tissues.人胃肠道组织的白三烯合成
Biochim Biophys Acta. 1986 Sep 12;878(2):184-93. doi: 10.1016/0005-2760(86)90145-1.
6
Opposing effects of indomethacin and nordihydroguaiaretic acid on macrophage function and tumor growth.消炎痛与去甲二氢愈创木酸对巨噬细胞功能及肿瘤生长的相反作用。
Jpn J Cancer Res. 1994 Mar;85(3):306-14. doi: 10.1111/j.1349-7006.1994.tb02098.x.
7
8
Production of leukotriene B4 and prostaglandin E2 by turbot (Scophthalmus maximus) leukocytes.大菱鲆（Scophthalmus maximus）白细胞产生白三烯B4和前列腺素E2 。
Comp Biochem Physiol B Biochem Mol Biol. 1999 Aug;123(4):351-6. doi: 10.1016/s0305-0491(99)00075-9.
9
Lipoxygenase pathway inhibition impairs the allograft response.脂氧合酶途径抑制会损害同种异体移植反应。
Surgery. 1987 Aug;102(2):248-55.
10
Arachidonic acid metabolites regulate interleukin-1 production.花生四烯酸代谢产物调节白细胞介素-1的产生。
Biochem Biophys Res Commun. 1985 Apr 30;128(2):892-7. doi: 10.1016/0006-291x(85)90130-5.
引用本文的文献
1
Interactions between rnacrophage cytokines and eicosanoids in expression of antitumour activity.巨噬细胞细胞因子与类花生酸在抗肿瘤活性表达中的相互作用。
Mediators Inflamm. 1992;1(5):295-308. doi: 10.1155/S0962935192000449.
2
Opposing effects of indomethacin and nordihydroguaiaretic acid on macrophage function and tumor growth.消炎痛与去甲二氢愈创木酸对巨噬细胞功能及肿瘤生长的相反作用。
Jpn J Cancer Res. 1994 Mar;85(3):306-14. doi: 10.1111/j.1349-7006.1994.tb02098.x.
3
Influence of zymosan (a non-specific macrophage stimulator) and of indomethacin on liver tumours--an experimental study in rats.酵母聚糖（一种非特异性巨噬细胞刺激剂）和吲哚美辛对肝肿瘤的影响——大鼠实验研究
J Cancer Res Clin Oncol. 1995;121(8):463-8. doi: 10.1007/BF01218362.
4
Inflammation amplifies the antitumor cytostasis by human peritoneal macrophages.炎症增强了人腹膜巨噬细胞的抗肿瘤细胞生长抑制作用。
Med Oncol Tumor Pharmacother. 1991;8(2):87-94. doi: 10.1007/BF02988859.
本文引用的文献
1
Characterization of macrophage subpopulations responsive to activation by endotoxin and lymphokines.对内毒素和淋巴因子激活有反应的巨噬细胞亚群的特征分析。
J Immunol. 1981 Jun;126(6):2474-9.
2
Chemiluminescence from mouse resident macrophages: characterization and modulation by arachidonate metabolites.
Immunopharmacology. 1983 Apr;5(4):277-91. doi: 10.1016/0162-3109(83)90044-9.
3
Human natural cytotoxic cell activity: enhancement by leukotrienes (LT) A4, B4 and D4, but not by stereoisomers of LTB4 or HETES.人类自然细胞毒性细胞活性：白三烯（LT）A4、B4和D4可增强其活性，但白三烯B4的立体异构体或羟二十碳四烯酸（HETES）则无此作用。
Prostaglandins Leukot Med. 1984 Jan;13(1):113-7. doi: 10.1016/0262-1746(84)90111-2.
4
Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.前列腺素对活化中性粒细胞释放白三烯B4的抑制作用。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4349-53. doi: 10.1073/pnas.80.14.4349.
5
Induction of macrophage growth by lipids.脂质诱导巨噬细胞生长。
J Immunol. 1986 Feb 15;136(4):1334-8.
6
7
Cyclooxygenase inhibitors promote the leukotriene C4 induced release of beta-glucuronidase from rat peritoneal macrophages: prostaglandin E2 suppresses.
Int J Immunopharmacol. 1986;8(3):305-11. doi: 10.1016/0192-0561(86)90112-8.
8
Prostaglandins as endogenous mediators of interleukin 1 production.前列腺素作为白细胞介素1产生的内源性介质。
J Immunol. 1986 Jan;136(1):186-92.
9
Leukotrienes augment interleukin 1 production by human monocytes.白三烯可增强人单核细胞白细胞介素1的产生。
J Immunol. 1985 Dec;135(6):3958-61.
10
Indomethacin increases the formation of lipoxygenase products in calcium ionophore stimulated human neutrophils.吲哚美辛可增加钙离子载体刺激的人中性粒细胞中脂氧合酶产物的生成。
Biochem Biophys Res Commun. 1987 Oct 29;148(2):534-8. doi: 10.1016/0006-291x(87)90909-0.
Zotero 插件