Norris D A, Fine R, Weston W L, Spector S
J Allergy Clin Immunol. 1978 Apr;61(4):255-60. doi: 10.1016/0091-6749(78)90200-2.
Monocyte cellular function in 15 asthmatics on alternate-day steroid therapy (mean dose of prednisone, 45.4 +/- 17.45 mg qod) was studied at 8 A.M. and noon after receiving an 8 A.M. steroid dose and at 8 A.M. the following day, and was contrasted to function in 16 healthy controls. Monocyte chemotaxis, bacterial killing and phagocytosis, and oil phagocytosis were not significantly altered by the steroid dose. On the other hand, all the patients experienced monocytopenia, lymphopenia, and neutrophilia 4 hr following the administration of steroid. The lack of functional impairment on this clinically relevant steroid regimen is consistent with the lack of serious infections seen in patients on such regimens. This study re-enforces the need to differentiate the effect of even small doses of steroid on circulating cell populations from direct effects on cell function which occur only with very high or frequent steroid dose regimens.
研究了15名接受隔日类固醇治疗（泼尼松平均剂量为45.4±17.45毫克，隔日一次）的哮喘患者的单核细胞功能。在上午8点服用类固醇剂量后，于上午8点和中午以及次日上午8点进行研究，并与16名健康对照者的功能进行对比。类固醇剂量并未显著改变单核细胞趋化性、细菌杀伤与吞噬作用以及油吞噬作用。另一方面，所有患者在服用类固醇4小时后均出现单核细胞减少、淋巴细胞减少和嗜中性粒细胞增多。这种临床相关类固醇治疗方案未导致功能损害，这与接受此类治疗方案的患者未出现严重感染的情况一致。这项研究进一步强调，即使是小剂量类固醇对循环细胞群体的影响与仅在非常高或频繁的类固醇给药方案下才会出现的对细胞功能的直接影响之间需要加以区分。
