新生儿单核细胞-巨噬细胞功能

Monocyte-macrophage function in the newborn.

作者信息

Weston W L, Carson B S, Barkin R M, Slater G D, Dustin R D, Hecht S K

出版信息

Am J Dis Child. 1977 Nov;131(11):1241-2. doi: 10.1001/archpedi.1977.02120240059011.

DOI:10.1001/archpedi.1977.02120240059011

PMID:920673

Abstract

Analysis of 20 human cord blood samples for monocyte-macrophage function demonstrates a selective defect in monocyte cellular chemotaxis. Monocyte bacterial phagocytosis, phagocytosis of paraffin oil particles, and bacterial killing of staphylococcus 502A were normal when compared with 30 healthy young adult controls. Impaired response of neonatal monocytes to chemotactants is an additional host defense defect that may help explain the undue susceptibility of neonates to certain infectious agents.

摘要

对20份人类脐带血样本进行单核细胞-巨噬细胞功能分析，结果显示单核细胞的细胞趋化性存在选择性缺陷。与30名健康年轻成人对照组相比，单核细胞对细菌的吞噬作用、对石蜡油颗粒的吞噬作用以及对金黄色葡萄球菌502A的细菌杀伤作用均正常。新生儿单核细胞对趋化剂的反应受损是另一种宿主防御缺陷，这可能有助于解释新生儿为何对某些感染因子过度易感。