Chiang J L, Patterson R, McGillen J J, Phair J P, Roberts M, Harris K, Riesing K S
J Allergy Clin Immunol. 1980 Apr;65(4):263-8. doi: 10.1016/0091-6749(80)90153-0.
The effect of long-term alternate-day steroid administration on lymphocyte and polymorphonuclear cell (PMN) functions was studied in 10 steroid-dependent adult asthmatic patients. The duration of alternate-day prednisone usage ranged from 3 to 12 yr with an average of 6.7 +/- 3.6 yr. Maintenance steroid dosage at the time of study ranged from 20 to 50 mg on alternate days, averaging 31 +/- 8 mg. Prednisone caused marked lymphopenia, suppression of phytohemagglutin (PHA) lymphocyte transformation and PMN adherence 4 hr after ingestion. By 24 hr these measurements returned to normal or higher. These effects appeared at all doses between 20 and 50 mg of prednisone. In contrast, there was no statistically significant suppression of the total leukocyte count, total and active erythrocyte (E) rosette-forming lymphocytes, serum immunoglobulin concentrations, polymorphonuclear cell (PMN) phagocytosis, or delayed skin reactivity. We conclude that the acute effects of prednisone on lymphocyte and PMN function are transient and return to normal levels by 24 hr. The continued administration of beclomethasone dipropionate by inhalation did not interfere with the recovery of the transient leukocyte abnormalities induced by oral prednisone.
在10名依赖类固醇的成年哮喘患者中，研究了长期隔日给予类固醇对淋巴细胞和多形核细胞（PMN）功能的影响。隔日服用泼尼松的时间为3至12年，平均为6.7±3.6年。研究时维持类固醇剂量为隔日20至50毫克，平均为31±8毫克。泼尼松导致明显的淋巴细胞减少、摄入后4小时对植物血凝素（PHA）淋巴细胞转化的抑制以及PMN黏附。到24小时时，这些指标恢复到正常或更高水平。在20至50毫克的所有泼尼松剂量下均出现这些效应。相比之下，对总白细胞计数、总及活性红细胞（E）花环形成淋巴细胞、血清免疫球蛋白浓度、多形核细胞（PMN）吞噬作用或迟发型皮肤反应没有统计学上的显著抑制。我们得出结论，泼尼松对淋巴细胞和PMN功能的急性效应是短暂的，到24小时时恢复到正常水平。通过吸入持续给予二丙酸倍氯米松并不干扰口服泼尼松诱导的短暂白细胞异常的恢复。
