人乳头瘤病毒1a型完整DNA序列：乳头多瘤空泡病毒科中一种新型的基因组结构
Human papillomavirus 1a complete DNA sequence: a novel type of genome organization among papovaviridae.
作者信息
Danos O, Katinka M, Yaniv M
出版信息
EMBO J. 1982;1(2):231-6. doi: 10.1002/j.1460-2075.1982.tb01152.x.
The complete nucleotide sequence of human papillomavirus type 1a (7811 nucleotides) has been established. The overall organization of the viral genome is different from that of other related papovaviruses (SV40, BKV, polyoma). Firstly, genetic information seems to be coded by one strand. Secondly, no significant homology is found with SV40 or polyoma coding sequence for either DNA or deducted protein sequences. The relatedness of human and bovine papillomaviruses is revealed by a conserved coding sequence in the two species. Two regions can be defined on the viral genome: the putative early region contains two large open reading frames of 1446 and 966 nucleotides, together with several split ones, and corresponds to the transforming part of the bovine papillomavirus type 1 genome, and the remaining sequences, which include two open reading frames likely to encode structural polypeptide(s). The DNA sequence is analysed and putative signals for regulation of gene expression, and homologies with the Alu family of human ubiquitous repeats and the SV40 72-bp repeat are outlines.
人乳头瘤病毒1a型的完整核苷酸序列（7811个核苷酸）已确定。病毒基因组的整体结构与其他相关乳头多瘤空泡病毒（SV40、BK病毒、多瘤病毒）不同。首先，遗传信息似乎由一条链编码。其次，无论是DNA还是推导的蛋白质序列，与SV40或多瘤病毒的编码序列均未发现明显同源性。人和牛乳头瘤病毒的相关性通过两个物种中保守的编码序列得以揭示。病毒基因组上可定义两个区域：推定的早期区域包含两个分别为1446和966个核苷酸的大开放阅读框，以及几个分散的开放阅读框，对应于牛乳头瘤病毒1型基因组的转化部分；其余序列包括两个可能编码结构多肽的开放阅读框。对DNA序列进行了分析，并概述了基因表达调控的推定信号，以及与人类普遍存在的Alu家族重复序列和SV40 72碱基对重复序列的同源性。
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