类风湿关节炎中循环多形核白细胞产生超氧阴离子的情况。
Superoxide anion production by circulating polymorphonuclear leucocytes in rheumatoid arthritis.
作者信息
Cencetti A, De Martino M, Graziani E, Maddali Bongi S, Palermo C, Pavari E, Zoppi M
机构信息
1st Medical Clinic, University of Florence, Italy.
出版信息
Clin Rheumatol. 1990 Mar;9(1):51-5. doi: 10.1007/BF02030242.
In twelve rheumatoid arthritis (RA) patients, receiving only nonsteroid anti-inflammatory therapy, superoxide anion (02-) generation by polymorphonuclear leucocytes (PMNs) was assessed by Cytochrome C reduction. The 02- production by non-activated PMNs in RA patients was significantly higher than in healthy controls. The 02- production by PMNs activated by zymosan and phorbol myristate acetate was significantly lower than in controls. PMNs from controls preincubated with rheumatoid sera generated higher 02- levels than the same PMNs incubated in normal sera.
在12例仅接受非甾体抗炎治疗的类风湿性关节炎（RA）患者中，通过细胞色素C还原法评估多形核白细胞（PMN）产生超氧阴离子（O₂⁻）的情况。RA患者中未激活的PMN产生的O₂⁻明显高于健康对照组。酵母聚糖和佛波酯肉豆蔻酸酯激活的PMN产生的O₂⁻明显低于对照组。与在正常血清中孵育的相同PMN相比，预先与类风湿血清孵育的对照组PMN产生的O₂⁻水平更高。
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