淋巴细胞对破伤风类毒素的反应与淋巴细胞供体年龄之间的关系。
Relationship between lymphocyte response to tetanus toxoid and age of lymphocyte donor.
作者信息
Peel M M, Edsall G, White W G, Barnes G M
出版信息
J Hyg (Lond). 1978 Apr;80(2):259-65. doi: 10.1017/s0022172400053614.
An investigation of the in vitro responsiveness of peripheral blood lymphocytes to tetanus toxoid was undertaken to determine the extent to which such reactivity might reflect in vivo reactions to tetanus toxoid immunization. It was found that lymphocyte transformation in the presence of tetanus toxoid, as measured by the uptake of tritiated thymidine, did not differ significantly for the group giving local or systemic reactions to tetanus toxoid and an immune control group. However, a striking inverse relation between lymphocyte reactivity to tetanus toxoid and age of the cell donors of both groups became clear. Such an age-related decline in the in vitro responsiveness of peripheral blood lymphocytes to a specific antigen has apparently had not been reported previously in man.
开展了一项关于外周血淋巴细胞对破伤风类毒素的体外反应性的研究，以确定这种反应性在多大程度上可能反映体内对破伤风类毒素免疫接种的反应。结果发现，通过氚标记胸腺嘧啶核苷摄取量来衡量，在破伤风类毒素存在的情况下，出现局部或全身反应的破伤风类毒素组与免疫对照组的淋巴细胞转化情况并无显著差异。然而，两组细胞供体的淋巴细胞对破伤风类毒素的反应性与年龄之间存在显著的负相关关系。此前在人类中显然尚未报道过外周血淋巴细胞对特定抗原的体外反应性存在这种与年龄相关的下降情况。
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