Fujimoto Y, Monden Y, Nakahara K, Nanjo S, Ohno K, Fujii Y, Hashimoto J, Kitagawa Y, Miyoshi S, Maeda H
Jpn J Antibiot. 1985 Jan;38(1):155-9.
The concentration of cefotiam (CTM) in the serum and the bloodless lung with time is discussed. Five patients who were undergone pneumonectomy or lobectomy, were given 1 g of CTM intravenously during the operation. Blood samples and lung samples were collected 15, 30, 60, 90, 120, and 300 minutes after the administration. The CTM levels in the blood and the lung samples were measured by the agar well bioassay. The CTM levels in the lung samples were modified as the CTM levels in the bloodless lung by calculating the contained blood volume, as lung samples were proven to have a mean value of 34.2% of blood in weight. The serum CTM level was 73.3 micrograms/ml at 15 minutes after injection and then decreased gradually. The CTM level in bloodless lung was elevated during the first 60 minutes, became equal to that of the blood during next 30 minutes and then exceeded the serum levels thereafter. These results indicate that the distribution of CTM to the bloodless lung was excellent and a satisfactory preventative effect against postsurgical infection could be expected.
讨论了血清和无血肺中头孢替安（CTM）浓度随时间的变化情况。5例行肺切除术或肺叶切除术的患者在手术期间静脉注射1克CTM。给药后15、30、60、90、120和300分钟采集血样和肺样。通过琼脂孔生物测定法测量血样和肺样中的CTM水平。由于肺样被证明平均含血量为重量的34.2%，通过计算所含血量将肺样中的CTM水平修正为无血肺中的CTM水平。注射后15分钟血清CTM水平为73.3微克/毫升，然后逐渐下降。无血肺中的CTM水平在最初60分钟内升高，在接下来30分钟内与血中水平相等，此后超过血清水平。这些结果表明CTM在无血肺中的分布良好，预计对术后感染有令人满意的预防效果。
