Kaidbey K H, Kligman A M
J Invest Dermatol. 1978 Mar;70(3):149-51. doi: 10.1111/1523-1747.ep12258568.
A method is described for the detection of topical photosensitizers in humans. Test agents were applied to the untanned midback under an occlusive dressing for 6 hr and then exposed to broad-spectrum radiation containing UV-A and visible wavelengths from a Xenon arc source. Well-known topical photosensitizers were readily identified. It was found that with certain poorly-penetrating substances, such as water-soluble dyes, applications to scarified skin were necessary to reveal phototoxic activity. In addition, these dyes were activated by wavelengths in the visible region of the spectrum.
本文描述了一种检测人体局部光敏剂的方法。将测试剂涂于未晒黑的背部中部，用封闭敷料覆盖6小时，然后暴露于含有来自氙弧光源的紫外线A和可见波长的广谱辐射下。知名的局部光敏剂很容易被识别出来。研究发现，对于某些穿透性差的物质，如水溶性染料，必须涂于划破的皮肤上才能显示出光毒性活性。此外，这些染料可被光谱可见区域的波长激活。
