Kaidbey K H, Kligman A M
J Invest Dermatol. 1978 May;70(5):272-4. doi: 10.1111/1523-1747.ep12541505.
An improved method is presented for the detection of systemically administered photosensitizing drugs in humans. Test agents were injected intradermally in physiologic saline and then exposed to broad spectrum radiation from a Xenon solar simulator. Several clinically recognized photosensitizers were identified by this technique. The activating spectrum depended on the test drug. Sulfonamides and vinblastin were activated by sunburning erythemic radiation (UV-B), while tetracyclines, nalidixic acid and phenothiazines by near UV (UV-A), and chlorothiazide by both. It is suggested that intradermal phototesting offers a means of verifying the phototoxic potential of agents suspected clinically of provoking a photosensitivity eruption.
本文介绍了一种改进的用于检测人体中全身给药的光敏药物的方法。将测试剂皮内注射到生理盐水中，然后暴露于氙气太阳模拟器发出的广谱辐射下。通过该技术鉴定出了几种临床公认的光敏剂。激活光谱取决于测试药物。磺胺类药物和长春碱由晒伤性红斑辐射（UV-B）激活，而四环素、萘啶酸和吩噻嗪由近紫外光（UV-A）激活，氯噻嗪则可由两者激活。有人提出，皮内光测试提供了一种手段，可用于验证临床上怀疑引发光敏性皮疹的药物的光毒性潜力。
