通过人体皮内试验鉴定全身性光毒性药物。

Identification of systemic phototoxic drugs by human intradermal assay.

作者信息

Kaidbey K H, Kligman A M

出版信息

J Invest Dermatol. 1978 May;70(5):272-4. doi: 10.1111/1523-1747.ep12541505.

Abstract

An improved method is presented for the detection of systemically administered photosensitizing drugs in humans. Test agents were injected intradermally in physiologic saline and then exposed to broad spectrum radiation from a Xenon solar simulator. Several clinically recognized photosensitizers were identified by this technique. The activating spectrum depended on the test drug. Sulfonamides and vinblastin were activated by sunburning erythemic radiation (UV-B), while tetracyclines, nalidixic acid and phenothiazines by near UV (UV-A), and chlorothiazide by both. It is suggested that intradermal phototesting offers a means of verifying the phototoxic potential of agents suspected clinically of provoking a photosensitivity eruption.

摘要

本文介绍了一种改进的用于检测人体中全身给药的光敏药物的方法。将测试剂皮内注射到生理盐水中，然后暴露于氙气太阳模拟器发出的广谱辐射下。通过该技术鉴定出了几种临床公认的光敏剂。激活光谱取决于测试药物。磺胺类药物和长春碱由晒伤性红斑辐射（UV-B）激活，而四环素、萘啶酸和吩噻嗪由近紫外光（UV-A）激活，氯噻嗪则可由两者激活。有人提出，皮内光测试提供了一种手段，可用于验证临床上怀疑引发光敏性皮疹的药物的光毒性潜力。