Fessler R G, Brown F D, Rachlin J R, Mullan S, Fang V S
Science. 1984 Jun 1;224(4652):1017-9. doi: 10.1126/science.6326266.
Beta-Endorphin-like immunoreactivity in cerebrospinal fluid was assayed in 11 patients receiving electrical stimulation of the brain for chronic pain. Immunoreactivity increased dramatically after contrast ventriculography prior to stimulation. No further elevations were observed after stimulation. The magnitude and time course of elevations were identical after placement of electrodes either in the thalamus or in the periventricular gray matter. These results suggest that previous findings of stimulation-induced elevation of beta-endorphin-like immunoreactivity in cerebrospinal fluid are attributable to an artifact of contrast ventriculography.
对11名因慢性疼痛接受脑电刺激的患者的脑脊液中β-内啡肽样免疫反应性进行了测定。在刺激前进行对比脑室造影后，免疫反应性急剧增加。刺激后未观察到进一步升高。将电极置于丘脑或脑室周围灰质后，升高的幅度和时间进程是相同的。这些结果表明，先前关于脑脊液中刺激诱导的β-内啡肽样免疫反应性升高的发现可归因于对比脑室造影的假象。
