Hosobuchi Y, Rossier J, Bloom F E, Guillemin R
Science. 1979 Jan 19;203(4377):279-81. doi: 10.1126/science.83674.
Immunoreactive beta-endorphin was measured in the ventricular fluid of six patients with chronic pain. Stimulation of the periaqueductal gray matter in three patients with pain of peripheral origin resulted in significant increases (50 to 300 percent) in the concentration of ventricular immunoreactive beta-endorphin. In three other patients suffering deafferentation dysesthesia, stimulation of the posterior limb of the internal capsule did not alter the concentration of this peptide. These results provide evidence of the release of human immunoreactive beta-endorphin in vivo and suggest that naloxone-reversible pain relief achieved by stimulation of the periaqueductal gray matter may be in part mediated by the activation of beta-endorphin-rich diencephalic areas.
对6例慢性疼痛患者的脑室液中的免疫反应性β-内啡肽进行了测定。对3例源于外周的疼痛患者的导水管周围灰质进行刺激，导致脑室免疫反应性β-内啡肽浓度显著升高（50%至300%）。在另外3例患有去传入性感觉异常的患者中，刺激内囊后肢并未改变该肽的浓度。这些结果为人体免疫反应性β-内啡肽在体内的释放提供了证据，并表明通过刺激导水管周围灰质实现的纳洛酮可逆性疼痛缓解可能部分是由富含β-内啡肽的间脑区域的激活介导的。
