Moldenhauer D
Zentralbl Bakteriol Mikrobiol Hyg B. 1984 Jan;178(5-6):502-9.
In Upper and Middle Franconia, two districts of northern Bavaria, with a population of 2.5 Millions, an increase of deaths caused by heart diseases according to code number 420-429 of the "International Classification of Diseases" has been ascertained by evaluation of data from the Bavarian State Office for Statistics and Data Processing. Figures rose from about 2000 cases in 1977 to more than 3000 in 1979. Sera from patients from these neighbouring regions (about 600 per year) have been examined for neutralizing antibodies against Coxsackie-B- and ECHO-viruses. An increase of positive results in ECHO 22 has been established. There were 4% with titer 20 or higher in 1977 and 30% in 1979. Figures of death rates as well as virus antibody titers have been followed until 1981 and remained almost unchanged. Though these two independently raised observations do not prove causal relations between ECHO-22-virus and death due to heart diseases, they may justify further considerations with regard to prospective studies in this field.
在上弗兰肯行政区和中弗兰肯行政区这两个位于巴伐利亚州北部的地区，人口达250万。通过对巴伐利亚州统计与数据处理办公室的数据评估，已确定按照“国际疾病分类”代码420 - 429，心脏病导致的死亡人数有所增加。死亡病例数从1977年的约2000例增至1979年的3000多例。对来自这些相邻地区的患者血清（每年约600份）进行了检测，以查找抗柯萨奇B病毒和埃可病毒的中和抗体。已证实埃可22型病毒的阳性检测结果有所增加。1977年滴度为20或更高的比例为4%，1979年为30%。死亡率以及病毒抗体滴度的数据跟踪至1981年，且几乎保持不变。尽管这两项独立得出的观察结果并未证明埃可22型病毒与心脏病死亡之间存在因果关系，但它们可能为该领域进一步的前瞻性研究提供合理依据。
