Meyer J L
Arch Biochem Biophys. 1984 May 15;231(1):1-8. doi: 10.1016/0003-9861(84)90356-4.
It was shown that it is apparently impossible for any calcification to occur in a system which contains a constant, physiological concentration of inorganic pyrophosphate. These results give further support to the earlier suggestion that inhibitors of calcium phosphate crystal growth must be removed from or denied access to the site of calcification to allow for the normal formation of the mineral phase. This study also suggests that the means of assessing the relative importance of a calcification inhibitor should be altered, since it is the equilibrium concentration of an inhibitor, and not its initial concentration in an assay system, which has physiological relevance.
结果表明，在含有恒定生理浓度无机焦磷酸的系统中，显然不可能发生任何钙化。这些结果进一步支持了早期的观点，即磷酸钙晶体生长抑制剂必须从钙化部位去除或阻止其进入，以允许矿物相正常形成。这项研究还表明，评估钙化抑制剂相对重要性的方法应该改变，因为具有生理相关性的是抑制剂的平衡浓度，而不是其在测定系统中的初始浓度。
