Cooper P H, Adelson G L, Holthaus W H
Arch Dermatol. 1984 Jun;120(6):774-7.
A patient had primary cutaneous adenoid cystic carcinoma. The tumor closely resembled adenoid cystic carcinoma of salivary gland origin and was composed of cribriform and tubular masses of basaloid cells. Lumina formed by neoplastic cells contained mucin and hyalin , and similar constituents were located between neoplastic cell masses and adjacent dermis. Perineural invasion was observed. A review of seven other primary cutaneous adenoid cystic carcinomas indicates that this neoplasm tends to affect middle-aged and older individuals, is often present for several years prior to diagnosis, has a propensity for local recurrence, but has not produced metastases in regional lymph nodes or distant sites. Therapy should employ wide surgical excision that extends well beyond the clinical confines of the neoplasm.
一名患者患有原发性皮肤腺样囊性癌。该肿瘤与涎腺来源的腺样囊性癌极为相似，由基底样细胞的筛状和管状团块组成。肿瘤细胞形成的管腔内含有黏液和透明质，类似成分也位于肿瘤细胞团块与相邻真皮之间。观察到有神经周围浸润。对其他7例原发性皮肤腺样囊性癌的回顾表明，这种肿瘤倾向于累及中年及老年个体，在诊断前常已存在数年，有局部复发倾向，但尚未在区域淋巴结或远处部位发生转移。治疗应采用广泛的手术切除，切除范围应远远超出肿瘤的临床边界。
