Antman K H, Ruxer R L, Aisner J, Vawter G
Cancer. 1984 Jul 15;54(2):367-9. doi: 10.1002/1097-0142(19840715)54:2<367::aid-cncr2820540232>3.0.co;2-y.
A high percentage of children with Wilms' tumor are cured with multimodal treatment. A small percentage of these children will develop second tumors, perhaps related to a genetic predisposition to neoplasia or possibly secondary to the treatment utilized for Wilms' tumor. Malignant mesothelioma has been associated with contact with asbestos but has also been reported after radiation exposure. Two patients are reported who developed malignant mesothelioma of the pleura after treatment for Wilms' tumor in childhood. Both received orthovoltage radiation; one patient also received triethylenemelamine (TEM), an alkylating agent closely related to nitrogen mustard, for 5 years. Factors in the development of second tumors are discussed.
高比例的肾母细胞瘤患儿通过多模式治疗得以治愈。这些患儿中有一小部分会发生二次肿瘤，这可能与肿瘤形成的遗传易感性有关，或者可能继发于用于治疗肾母细胞瘤的疗法。恶性间皮瘤与接触石棉有关，但在辐射暴露后也有报道。本文报告了两名患者，他们童年时期接受肾母细胞瘤治疗后发生了胸膜恶性间皮瘤。两人均接受了深部X线放疗；一名患者还接受了5年的三乙烯三聚氰胺（TEM）治疗，TEM是一种与氮芥密切相关的烷化剂。文中讨论了二次肿瘤发生的相关因素。
