Hofmann J, Mintzer D, Warhol M J
Department of Internal Medicine, Pennsylvania Hospital, Philadelphia.
Am J Med. 1994 Oct;97(4):379-82. doi: 10.1016/0002-9343(94)90307-7.
Studies of the growing population of long-term survivors of cancer have led to increased recognition of the neoplastic complications of therapy. The causes of secondary malignancies are probably multifactorial, but radiation therapy and chemotherapy have certainly been implicated in the development of posttherapy neoplasia.
A case of pleural mesothelioma after successful radiation therapy for Hodgkin's disease is described with a review of radiation-associated mesotheliomas reported in the literature. In Hodgkin's disease, patients may receive radiation, chemotherapy, or combined treatment; the most common secondary malignancy is acute nonlymphocytic leukemia while sarcomas are the second most common solid tumors.
Although mesothelioma is an uncommon sarcoma, its occurrence has been documented numerous times after exposure to diagnostic or therapeutic radiation.
对癌症长期存活者不断增加的群体进行的研究，已使人们对治疗的肿瘤并发症有了更多认识。继发性恶性肿瘤的病因可能是多因素的，但放射治疗和化学治疗肯定与治疗后肿瘤形成有关。
本文描述了1例霍奇金病成功放疗后发生胸膜间皮瘤的病例，并对文献报道的与放疗相关的间皮瘤进行了综述。在霍奇金病中，患者可能接受放疗、化疗或联合治疗；最常见的继发性恶性肿瘤是急性非淋巴细胞白血病，而肉瘤是第二常见的实体瘤。
尽管间皮瘤是一种不常见的肉瘤，但在接触诊断性或治疗性辐射后，其发生已有多次记录。
