仙台病毒特异性T细胞克隆。V. 针对T辅助细胞克隆的抗独特型抗体诱导病毒特异性反应。
Sendai virus-specific T cell clones. V. Induction of a virus-specific response by antiidiotypic antibodies directed against a T helper cell clone.
作者信息
Ertl H C, Homans E, Tournas S, Finberg R W
出版信息
J Exp Med. 1984 Jun 1;159(6):1778-83. doi: 10.1084/jem.159.6.1778.
Abstract
We used an antiidiotypic antibody directed against a Sendai virus-specific T helper cell clone to stimulate an immune response in vivo. In addition, the antiidiotypic antibody induced T cells that mediated a delayed-type hypersensitivity (DTH) response in several different mouse strains. Induction of the DTH response by the antiidiotypic antibody, in contrast to the DTH responses induced by virus, demonstrated a remarkable lack of H-2 restriction.
摘要
我们使用了一种针对仙台病毒特异性T辅助细胞克隆的抗独特型抗体，以在体内刺激免疫反应。此外，该抗独特型抗体诱导的T细胞在几种不同的小鼠品系中介导了迟发型超敏反应（DTH）。与病毒诱导的DTH反应相反，抗独特型抗体诱导的DTH反应显示出明显缺乏H-2限制性。
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