Thomas W R, Morahan G, Walker I D, Miller J F
J Exp Med. 1981 Mar 1;153(3):743-7. doi: 10.1084/jem.153.3.743.
Azobenzenearsonate (ABA)-specific sensitivity was induced in A/J mice by injecting a monoclonal anti-idiotype reagent, 14A, directed against a determinant present on a minor subpopulation of immunoglobulin molecules within the anti-ABA antibodies of A/J mice. Sensitivity was transferrable by purified T cells and this was abrogated by treating the cells with 14A, rabbit anti-mouse immunoglobulin and complement, not by treatment with only the last two reagents. The transfer was restricted by the K-end of the major histocompatibility complex.
通过注射一种单克隆抗独特型试剂14A,在A/J小鼠中诱导了对偶氮苯砷酸盐(ABA)的特异性敏感性,该试剂针对A/J小鼠抗ABA抗体中免疫球蛋白分子的一个小亚群上存在的一个决定簇。敏感性可通过纯化的T细胞转移,并且通过用14A、兔抗小鼠免疫球蛋白和补体处理细胞可消除这种转移,仅用后两种试剂处理则不能。这种转移受主要组织相容性复合体K端的限制。