Dietemann-Molard A, Pelletier A, Pauli G, Imbs J L, Roegel E
Rev Pneumol Clin. 1984;40(2):121-5.
Serum levels of angiotensin conversion enzyme (A.C.E.) are increased in 60 to 80% of cases of sarcoidosis. A.C.E. levels were measured as part of the initial assessment of 70 patients with the disease, with repeated measurements in 18 of them. The subsequent course of sarcoidosis was evaluated over a minimum period of 7 months, in relation to initial serum A.C.E. levels. A high serum A.C.E. level is indicative of the secretion of the cells of the epithelioid and giant cell granuloma and reflects the activity of the disease at the particular time without providing any definite prognostic information. Study of 6 patients treated with corticosteroids showed that serum A.C.E. levels rose again when treatment was reduced or stopped in 4 of them, this renewed rise appearing to precede the radiological recurrence. Whilst the prognostic value of alveolar lymphocytosis is greater than that of serum A.C.E. levels in sarcoidosis, measurement of serum A.C.E. is easier in the context of therapeutic surveillance.
在60%至80%的结节病病例中，血清血管紧张素转换酶（A.C.E.）水平会升高。对70例该病患者进行初始评估时测定了A.C.E.水平，其中18例进行了重复测量。结节病的后续病程在至少7个月的时间内进行评估，与初始血清A.C.E.水平相关。血清A.C.E.水平高表明上皮样细胞和巨细胞肉芽肿细胞的分泌情况，反映了疾病在特定时间的活动情况，但未提供任何明确的预后信息。对6例接受皮质类固醇治疗的患者进行研究发现，其中4例在治疗减量或停药时血清A.C.E.水平再次升高，这种再次升高似乎先于放射学复发。虽然在结节病中肺泡淋巴细胞增多症的预后价值大于血清A.C.E.水平，但在治疗监测方面，测定血清A.C.E.更容易。
