Leclerc P, Baumann C, Orvoen-Frija E, Blais J, Ameille J, Rochemaure J
Sem Hop. 1982 May 27;58(21):1291-4.
The serum angiotensin converting enzyme (ACE) activity was assayed in seventy untreated patients with sarcoïdosis. Results were considered abnormal if they exceeded 34,5 U/ml. (SEM + 250). Increased ACE activity was found in 55,7% of the patients. Most of these patients had either Stage II or disseminated disease. Significant decreases in ACE activity always occurred during remission, whether spontaneous or induced by corticosteroids. In most patients with persistant roentgenologic features ACE activity was still high six months after onset. No correlations were found between serum ACE activities and lymphocytosis in bronchial washing samples. We conclude that, while serum ACE activity assays are not of significant diagnostic utility in patients with sarcoidosis, they are helpful for monitoring the course of the disease.
对70例未经治疗的结节病患者的血清血管紧张素转换酶（ACE）活性进行了检测。如果结果超过34.5 U/ml（标准误+250），则被认为异常。55.7%的患者ACE活性升高。这些患者大多处于Ⅱ期或播散性疾病。无论缓解是自发的还是由皮质类固醇诱导的，在缓解期ACE活性总是显著降低。在大多数具有持续影像学特征的患者中，发病6个月后ACE活性仍然很高。在支气管灌洗样本中，未发现血清ACE活性与淋巴细胞增多之间存在相关性。我们得出结论，虽然血清ACE活性检测对结节病患者没有显著的诊断价值，但有助于监测疾病的进程。
