Schepp W, Miederer S E, Ruoff H J
Agents Actions. 1984 Apr;14(3-4):522-8. doi: 10.1007/BF01973863.
Intrinsic Factor (IF) secretion was studied using isolated gastric mucosal cells from rat and man. In the rat, IF was localized to the chief cells and its secretion responded most efficaciously to carbachol. DbcAMP and hexoprenaline were less powerful, whereas histamine and pentagastrin lacked any effect. In man, IF secretion derived from the parietal cells and was increasingly enhanced by hexoprenaline, pentagastrin, carbachol, histamine and dbcAMP. In both species, IF secretion differs with respect to its cellular origin and the pattern of secretagogue control: IF release from rat chief cells is due to muscarinic receptor excitation, whereas IF release from human parietal cells responds predominantly to histamine-H2-receptor activation and seems to be mediated by the cAMP system.
采用大鼠和人的离体胃黏膜细胞研究了内因子（IF）的分泌。在大鼠中，IF定位于主细胞，其分泌对卡巴胆碱反应最为有效。双丁酰环磷腺苷（dbcAMP）和海索那林的作用较弱，而组胺和五肽胃泌素则无任何作用。在人类中，IF分泌源自壁细胞，并且可被海索那林、五肽胃泌素、卡巴胆碱、组胺和dbcAMP逐渐增强。在这两个物种中，IF分泌在细胞来源和促分泌素控制模式方面存在差异：大鼠主细胞释放IF是由于毒蕈碱受体兴奋，而人类壁细胞释放IF主要对组胺-H2受体激活作出反应，并且似乎由环磷腺苷（cAMP）系统介导。
