Gates G F, Fishman L S, Segall H D
J Nucl Med. 1978 Mar;19(3):235-44.
Nine children with arteriovenous malformations (AVMs), and a tenth with a cerebral aneurysm, had computer-processed dynamic scintigraphy with static scintigrams, transmission computed tomography (CT) both with and without contrast injection, and radiopaque cerebral angiography. All ten lesions were detected by dynamic scintigraphy and angiography, whereas two AVMs were missed on CT scans and the aneurysm and two AVMs (one missed by CT) were not identified on static scintigrams. Time-activity curves generated from regions of interest placed over the cerebral hemispheres, AVMs and/or various venous structures permitted, respectively, estimation of interhemispheric partition of perfusion, estimation of the fraction of total cerebral hemispheric perfusion preferentially directed into a malformation, and indication of the route of venous drainage from the lesions. While dynamic scintigraphy and CT scanning both identified the aneurysm, scintigraphy was the most effective screening test for detecting AVMs owing to its accuracy, lower cost, and lack of required anesthesia, heavy sedation or iodinated contrast agents.
9名患有动静脉畸形（AVM）的儿童和1名患有脑动脉瘤的儿童接受了计算机处理的动态闪烁扫描，并拍摄了静态闪烁图，还进行了注射造影剂前后的透射计算机断层扫描（CT）以及脑内造影血管造影。所有10个病变均通过动态闪烁扫描和血管造影检测到，而在CT扫描中漏诊了2个AVM，在静态闪烁图上未识别出动脉瘤以及2个AVM（其中1个被CT漏诊）。从置于大脑半球、AVM和/或各种静脉结构上的感兴趣区域生成的时间-活性曲线，分别可以估计半球间灌注分配、优先进入畸形的全脑半球灌注分数，并显示病变的静脉引流途径。虽然动态闪烁扫描和CT扫描都识别出了动脉瘤，但由于其准确性、低成本以及无需麻醉、深度镇静或碘化造影剂，闪烁扫描是检测AVM最有效的筛查方法。
