Nohtomi A, Itoh M, Yufu N
Brain Res. 1984 May 21;300(1):152-6. doi: 10.1016/0006-8993(84)91350-7.
The effects of sulpiride, a specific dopamine receptor antagonist, on the levels of immunoreactive beta-endorphin (ir-beta-END) in discrete hypothalamic nuclei of rats were investigated. Single injections of sulpiride significantly decreased the levels of ir-beta-END in the nucleus arcuatus, nucleus paraventricularis and median eminence. Repeated injections of sulpiride significantly increased the levels of ir-beta-END in the nucleus arcuatus, nucleus periventricularis and median eminence. These findings suggest that beta-endorphinergic neurons are under dopaminergic control.
研究了特异性多巴胺受体拮抗剂舒必利对大鼠离散下丘脑核中免疫反应性β-内啡肽（ir-β-END）水平的影响。单次注射舒必利可显著降低弓状核、室旁核和正中隆起中ir-β-END的水平。重复注射舒必利可显著提高弓状核、室周核和正中隆起中ir-β-END的水平。这些发现表明β-内啡肽能神经元受多巴胺能控制。
