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通过补体介导的异种抗血清吸收揭示的小鼠淋巴抗原的潜在同源性。

Latent homology of murine lymphoid antigens revealed through the complement mediated absorption of xenogeneic antiserum.

作者信息

Drake W P, Roberts G C, Mardiney M R

出版信息

Biomedicine. 1976 Nov 10;24(5):329-33.

PMID:63296
Abstract

Xenoantiserum against C57BL/6 mouse spleen cells was produced by immunization of rabbits. Such antiserum displayed cytotoxic activity for several strains of mice. Standard "in vitro" absorption removed species specific antibody revealing antibody directed against the C57BL/6 strain. When the xenoantiserum was absorbed with DBA/2 spleen cells in the presence of complement, the binding of anti-C57BL/6 was increased. Such data suggest that xenoantibodies directed against spleen cells possess a broader capacity to react with cross-strain lymphoid antigens than previously described.

摘要

通过免疫兔子制备了抗C57BL/6小鼠脾细胞的异种抗血清。这种抗血清对几种小鼠品系表现出细胞毒性活性。标准的“体外”吸收去除了种属特异性抗体，揭示了针对C57BL/6品系的抗体。当异种抗血清在补体存在下用DBA/2脾细胞吸收时，抗C57BL/6的结合增加。这些数据表明，针对脾细胞的异种抗体与跨品系淋巴抗原反应的能力比先前描述的更强。

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Biomedicine. 1976 Nov 10;24(5):329-33.
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