Cigarette smoke components are not very effective in directly inactivating alpha 1-proteinase inhibitor.
作者信息
Wyss A, Virca G D, Schnebli H P
出版信息
Hoppe Seylers Z Physiol Chem. 1984 Apr;365(4):511-6. doi: 10.1515/bchm2.1984.365.1.511.
PMID:6329941
Abstract
Cigarette smoke was found to be rather ineffective in inactivating alpha 1-proteinase inhibitor (alpha 1-PI) in aqueous solution, whereas a slow inactivation of alpha 1-PI by a dimethyl sulfoxide extract of whole cigarette smoke condensate was observed. However, this inactivation could only partially be prevented by antioxidants indicating that it is not, or at least not exclusively, due to oxidation. The bulk of inactive alpha 1-PI found in lung lavage fluids from smokers is thus probably generated through endogenous mechanisms and not through smoke components directly.
摘要
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Cigarette smoke components are not very effective in directly inactivating alpha 1-proteinase inhibitor.
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