在新型β-内酰胺类抗生素存在的情况下测定血清中氨基糖苷类药物和万古霉素的水平。
Measurement of levels of aminoglycosides and vancomycin in serum in the presence of new beta-lactam antibiotics.
作者信息
Calderwood S B, Tung C C, Jackson E
出版信息
J Clin Microbiol. 1984 May;19(5):707-9. doi: 10.1128/jcm.19.5.707-709.1984.
Abstract
We evaluated the effect of new beta-lactam antibiotics (azlocillin, mezlocillin, piperacillin, cefotaxime, moxalactam, and cefoperazone) on assays for aminoglycosides and vancomycin. These antibiotics produced no interference in an immunoassay for gentamicin and tobramycin. The new penicillins produced no interference in a bioassay of amikacin and vancomycin with penicillinase incorporated into the assay agar. Bioassay in the presence of the cephalosporins required predigestion with cephalosporinase. We describe a method for accurate bioassay in the presence of the available cephalosporins, with the exception of moxalactam.
摘要
我们评估了新型β-内酰胺类抗生素（阿洛西林、美洛西林、哌拉西林、头孢噻肟、莫西沙星和头孢哌酮）对氨基糖苷类和万古霉素检测的影响。这些抗生素对庆大霉素和妥布霉素的免疫检测无干扰。新型青霉素对含青霉素酶的阿米卡星和万古霉素生物检测无干扰。在头孢菌素存在的情况下进行生物检测需要用头孢菌素酶预先消化。我们描述了一种在除莫西沙星外的现有头孢菌素存在的情况下进行准确生物检测的方法。
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Comparison of different tobramycin assays.不同妥布霉素检测方法的比较。
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Bioassay for determination of vancomycin in the presence of rifampin or aminoglycosides.在利福平或氨基糖苷类药物存在的情况下测定万古霉素的生物测定法。
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