完整的人红细胞可预防过氧化氢介导的对离体灌注大鼠肺和培养的牛肺动脉内皮细胞的损伤。
Intact human erythrocytes prevent hydrogen peroxide-mediated damage to isolated perfused rat lungs and cultured bovine pulmonary artery endothelial cells.
作者信息
Toth K M, Clifford D P, Berger E M, White C W, Repine J E
出版信息
J Clin Invest. 1984 Jul;74(1):292-5. doi: 10.1172/JCI111414.
Abstract
Addition of untreated or glutaraldehyde-fixed human erythrocytes decreased hydrogen peroxide (H2O2)-mediated acute edematous injury in isolated rat lungs, H2O2-induced damage to cultured bovine pulmonary artery endothelial cells, and H2O2-dependent oxidation of reduced cytochrome C in vitro. The results suggest that intact erythrocytes can scavenge H2O2, and as a result, protect the lung and possibly other tissues from damage.
摘要
添加未处理的或经戊二醛固定的人红细胞可减轻过氧化氢（H2O2）介导的离体大鼠肺急性水肿损伤、H2O2诱导的培养牛肺动脉内皮细胞损伤以及体外H2O2依赖的还原型细胞色素C氧化。结果表明，完整的红细胞可以清除H2O2，从而保护肺及可能的其他组织免受损伤。
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