Holness D L, Broder I, Corey P N, Booth N, Mozzon D, Nazar M A, Guirguis S
J Occup Med. 1984 Jun;26(6):449-55. doi: 10.1097/00043764-198406000-00018.
Respiratory variables in 95 isocyanate workers and 37 control workers were compared. The exposed workers had a slightly higher frequency of cough and shortness of breath than the controls and a significantly lower frequency of family history of asthma, hay fever, and bronchitis. The isocyanate workers had slightly lower baseline lung function than the control workers but demonstrated significantly larger declines in their pulmonary function over the work shift. Both groups showed some intraday and intraweek variation in lung function. The changes in lung function over the work shift varied with different job categories, the largest changes occurring in finishing-area workers. A gradation of response was observed when exposure was categorized as nil, low, or high, but no exposure-effect relationships could be demonstrated by regression analysis of either area or personal results.
对95名异氰酸酯工人和37名对照工人的呼吸变量进行了比较。与对照组相比，接触异氰酸酯的工人咳嗽和呼吸急促的频率略高，而哮喘、花粉症和支气管炎家族史的频率显著较低。异氰酸酯工人的基线肺功能略低于对照工人，但在工作班次期间其肺功能下降幅度显著更大。两组的肺功能在日内和周内均有一些变化。工作班次期间肺功能的变化因工作类别而异，最大的变化发生在整理区工人中。当将接触分为无、低或高时，观察到了反应梯度，但通过对区域或个人结果的回归分析无法证明接触-效应关系。
