Nakano E, Tada Y, Fujioka H, Matsuda M, Osafune M, Kotake T, Sato B, Takaha M, Sonoda T
J Urol. 1984 Aug;132(2):240-5. doi: 10.1016/s0022-5347(17)49577-2.
Analyses of hormone receptors in cytosols from 41 renal cell carcinoma specimens were performed by the dextran-coated charcoal technique, using estradiol, synthetic progestin R5020 and synthetic androgen R1881. Binding data were calculated according to the method of Scatchard. Of 41 renal cell carcinomas estradiol receptor was detected in 11, R5020 receptor in 11 and R1881 receptor in 13. No significant correlation between histopathological findings and hormone receptors was observed. Patients were classified into those positive and negative for receptors. The clinical response of endocrine therapy for 17 with advanced residual or metastatic lesions after nephrectomy was studied in regard to the survival rates. Although there was no complete or partial regression in tumor size, the survival rate of patients with 1 or more receptors was significantly higher than that of patients negative for receptors (p less than 0.01). In conclusion, hormonal manipulation in patients with renal cell carcinoma cannot induce an antitumor effect but seems to increase survival in patients with receptors.
采用葡聚糖包被活性炭技术，使用雌二醇、合成孕激素R5020和合成雄激素R1881，对41例肾细胞癌标本的胞质溶胶中的激素受体进行了分析。结合数据根据Scatchard方法计算。在41例肾细胞癌中，检测到11例有雌二醇受体，11例有R5020受体，13例有R1881受体。未观察到组织病理学结果与激素受体之间存在显著相关性。将患者分为受体阳性和阴性两组。研究了17例肾切除术后有晚期残留或转移病灶患者的内分泌治疗的临床反应与生存率的关系。尽管肿瘤大小没有完全或部分缩小，但有1种或更多受体的患者的生存率显著高于受体阴性的患者（p<0.01）。总之，肾细胞癌患者的激素操纵不能诱导抗肿瘤作用，但似乎能提高有受体患者的生存率。
